|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6307a was selected from the Center region of human ABAD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Amyloid b-peptide-binding alcohol dehydrogenase (ABAD) is a member of the family of short chain dehydrogenase/reductases; unique among this family, it binds amyloid b-peptide and exhibits enzymatic activity toward a wide variety of substrates including linear alcohols. In an amyloid beta-abundant environment, ABAD appears to trigger cell stress induced by the amyloid peptide.
FASEB J. 19 (6), 597-598 (2005)J. Mol. Biol. 342 (3), 943-952 (2004)Science 304 (5669), 448-452 (2004)FEBS Lett. 451 (3), 238-242 (1999)J. Biol. Chem. 274 (21), 15014-15019 (1999)
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