ABAD Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6IBS9 |
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Clone Names | 4050303 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6307b was selected from the C-term region of human ABAD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
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Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Amyloid b-peptide-binding alcohol dehydrogenase (ABAD) is a member of the family of short chain dehydrogenase/reductases; unique among this family, it binds amyloid b-peptide and exhibits enzymatic activity toward a wide variety of substrates including linear alcohols. In an amyloid beta-abundant environment, ABAD appears to trigger cell stress induced by the amyloid peptide.
References
FASEB J. 19 (6), 597-598 (2005)J. Mol. Biol. 342 (3), 943-952 (2004)Science 304 (5669), 448-452 (2004)FEBS Lett. 451 (3), 238-242 (1999)J. Biol. Chem. 274 (21), 15014-15019 (1999)
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