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Signal peptide peptidase-like 2B (SPPL2b) Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8TCT7
Clone Names 2092804
Additional Information
Gene ID 56928
Other Names Signal peptide peptidase-like 2B, SPP-like 2B, SPPL2b, 3423-, Intramembrane protease 4, IMP-4, Presenilin homologous protein 4, PSH4, Presenilin-like protein 1, SPPL2B, IMP4, KIAA1532, PSL1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6312b was selected from the Center region of human SPPL2b. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms IMP4, KIAA1532, PSL1
Function Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.
Cellular Location Golgi apparatus membrane; Multi- pass membrane protein. Note=targeted through the entire secretory pathway to endosomes/lysosomes
Tissue Location Expressed predominantly in adrenal cortex and mammary gland.
Research Areas
Citations (0)

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Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. Several presenilin homologues/SPP-like proteins (PSHs/SPPL) have been identified. Unlike the ER localization of SPP and other SPPL proteins, SPPL2b is targeted through the secretory pathway to endosomes/lysosomes.


Friedmann, E., et al., J. Biol. Chem. 279(49):50790-50798 (2004).Grigorenko, A.P., et al., Biochemistry Mosc. 67(7):826-835 (2002).Weihofen, A., et al., Science 296(5576):2215-2218 (2002).

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$ 80.00
Cat# BP6312b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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