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SPP Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8TCT9
Clone Names 2092412
Additional Information
Gene ID 81502
Other Names Minor histocompatibility antigen H13, 3423-, Intramembrane protease 1, IMP-1, IMPAS-1, hIMP1, Presenilin-like protein 3, Signal peptide peptidase, HM13, H13, IMP1, PSL3, SPP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6314b was selected from the C-term region of human SPP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HM13
Synonyms H13, IMP1, PSL3, SPP
Function Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side
Tissue Location Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla
Research Areas
Citations (0)

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SPP, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. This protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases.


Friedmann, E., et al., J. Biol. Chem. 279(49):50790-50798 (2004).Nyborg, A.C., et al., J. Biol. Chem. 279(15):15153-15160 (2004).Urny, J., et al., Gene Expr. Patterns 3(5):685-691 (2003).Grigorenko, A.P., et al., Biochemistry Mosc. 67(7):826-835 (2002).Weihofen, A., et al., Science 296(5576):2215-2218 (2002).

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$ 80.00
Cat# BP6314b
Availability: In Stock
Bulk Size
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