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DSCR1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P53805
Other Accession Q7Z555
Clone Names 3090812
Peptide ID 3090812
Additional Information
Gene ID 1827
Other Names Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6315c was selected from the C-term region of human DSCR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCAN1
Synonyms ADAPT78, CSP1, DSC1, DSCR1
Function Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Tissue Location Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues
Research Areas
Citations ( 0 )


DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.


Minami, T., et al., J. Biol. Chem. 279(48):50537-50554 (2004).Yao, Y.G., et al., Biochem. Biophys. Res. Commun. 321(3):648-656 (2004).Michtalik, H.J., et al., Free Radic. Biol. Med. 37(4):454-462 (2004).Hesser, B.A., et al., Blood 104(1):149-158 (2004).Iizuka, M., et al., Biochem. Biophys. Res. Commun. 41(4):334-344 (2004).

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$ 80.00
Cat# BP6315c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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