|Other Names||Down syndrome critical region protein 4, Down syndrome critical region protein B, DSCR4, DCRB, DSCRB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6319c was selected from the N-term region of human DSCR4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Mainly expressed in placenta. EMBL; AB000099; BAA25877.1; -; mRNA EMBL; BC069729; AAH69729.1; -; mRNA EMBL; BC096162; AAH96162.1; -; mRNA EMBL; BC096163; AAH96163.1; -; mRNA EMBL; BC096164; AAH96164.1; -; mRNA CCDS; CCDS33554.1; - RefSeq; NP_005858.1; NM_005867.3 UniGene; Hs.23251; - UniGene; Hs.744972; - ProteinModelPortal; P56555; - BioGrid; 115570; 2 IntAct; P56555; 1 STRING; 9606.ENSP00000381921; - iPTMnet; P56555; - PhosphoSitePlus; P56555; - BioMuta; DSCR4; - PaxDb; P56555; - PRIDE; P56555; - DNASU; 10281; - Ensembl; ENST00000328264; ENSP00000328676; ENSG00000184029 GeneID; 10281; - KEGG; hsa:10281; - UCSC; uc002ywp.3; human CTD; 10281; - DisGeNET; 10281; - GeneCards; DSCR4; - HGNC; HGNC:3045; DSCR4 HPA; HPA018460; - MIM; 604829; gene neXtProt; NX_P56555; - OpenTargets; ENSG00000184029; - PharmGKB; PA27497; - eggNOG; ENOG410KC5P; Eukaryota eggNOG; ENOG4110T2K; LUCA GeneTree; ENSGT00390000011636; - HOGENOM; HOG000112278; - InParanoid; P56555; - BioCyc; ZFISH:G66-32646-MONOMER; - GenomeRNAi; 10281; - PRO; PR:P56555; - Proteomes; UP000005640; Chromosome 21 Bgee; ENSG00000184029; - CleanEx; HS_DSCR4; - ExpressionAtlas; P56555; baseline and differential Genevisible; P56555; HS 2: Evidence at transcript level; Complete proteome; Reference proteome CHAIN 1 118 Down syndrome critical region protein 4 /FTId=PRO_0000080019 SEQUENCE 118 AA; 12955 MW; 97CE8D8A85F447BF CRC64; MSLIILTRDD EPRIFTPDSD AASPALHSTS PLPDPASASP LHREEKILPK VCNIVSCLSF SLPASPTDSG LASPTIITRE GQQFWAKCLI WKYQLYLHGL HKKSDGRRDK QISASPST|
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Provided below are standard protocols that you may find useful for product applications.
The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and mental retardation. The gene for this protein is found in this region and multiple transcripts may exist. It is mainly expressed in the placenta.
Dahmane, N., et al., Genomics 48(1):12-23 (1998).Nakamura, A., et al., DNA Res. 4(5):321-324 (1997).
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