DSCR4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P56555 |
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Clone Names | 2093004 |
Other Names | Down syndrome critical region protein 4, Down syndrome critical region protein B, DSCR4, DCRB, DSCRB |
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Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6319d was selected from the C-term region of human DSCR4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DSCR4 |
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Synonyms | DCRB, DSCRB |
Tissue Location | Mainly expressed in placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and mental retardation. The gene for DSCR4 is found in this region and multiple transcripts may exist. It is mainly expressed in the placenta.
References
Dahmane, N., et al., Genomics 48(1):12-23 (1998).Nakamura, A., et al., DNA Res. 4(5):321-324 (1997).
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