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Kallikrein 2 (KLK2) Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P20151 |
|---|---|
| Other Accession | NP_005542 |
| Clone Names | 4032904 |
| Gene ID | 3817 |
|---|---|
| Other Names | Kallikrein-2, Glandular kallikrein-1, hGK-1, Tissue kallikrein-2, KLK2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KLK2 |
|---|---|
| Function | Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Kallikreins are a group of serine proteases manifesting diverse physiological functions. The glandular kallikreins are a distinct group of serine proteases with an ability to release vasoactive peptides from kininogen in vitro, although the kininogenase activity of different kallikreins is highly variable. Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Many kallikrein genes are differentially expressed in various malignancies. Human glandular kallikrein (hK2; encoded by the KLK2 gene) is an emerging tumor marker for prostate cancer.
References
Haese, A., et al., J Urol. 2005 Mar;173(3):752-6. Chiang, C.H., et al., J Urol. 2005 Feb;173(2):429-32.Clements, J.A., et al., Crit Rev Clin Lab Sci. 2004;41(3):265-312. Borgono, C.A., et al., Mol Cancer Res. 2004 May;2(5):257-80.Yousef, G.M., Clin Biochem. 2003 Sep;36(6):443-52.
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