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DSCR5 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P57054 |
|---|---|
| Clone Names | 2093005 |
| Gene ID | 51227 |
|---|---|
| Other Names | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region protein 5, Down syndrome critical region protein C, Phosphatidylinositol-glycan biosynthesis class P protein, PIG-P, PIGP, DCRC, DSCR5, DSCRC |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6322a was selected from the N-term region of human DSCR5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PIGP (HGNC:3046) |
|---|---|
| Synonyms | DCRC, DSCR5, DSCRC |
| Function | Part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
DSCR5 is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. DSCR5 is an N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). The DSCR5 gene is located in the Down Syndrome critical region (DSCR) on chromosome 21 and is a candidate for the pathogenesis of Down syndrome.
References
Choi, D.K., et al., Mamm. Genome 12(5):347-351 (2001).Togashi, T., et al., DNA Res. 7(3):207-212 (2000).Watanabe, R., et al., EMBO J. 19(16):4402-4411 (2000).Shibuya, K., et al., Biochem. Biophys. Res. Commun. 271(3):693-698 (2000).
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