|Other Names||Phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region protein 5, Down syndrome critical region protein C, Phosphatidylinositol-glycan biosynthesis class P protein, PIG-P, PIGP, DCRC, DSCR5, DSCRC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6322a was selected from the N-term region of human DSCR5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DCRC, DSCR5, DSCRC|
|Function||Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
DSCR5 is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. DSCR5 is an N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). The DSCR5 gene is located in the Down Syndrome critical region (DSCR) on chromosome 21 and is a candidate for the pathogenesis of Down syndrome.
Choi, D.K., et al., Mamm. Genome 12(5):347-351 (2001).Togashi, T., et al., DNA Res. 7(3):207-212 (2000).Watanabe, R., et al., EMBO J. 19(16):4402-4411 (2000).Shibuya, K., et al., Biochem. Biophys. Res. Commun. 271(3):693-698 (2000).
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