|Other Names||Prostate-specific antigen, PSA, Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase, KLK3, APS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6322b was selected from the C-term region of human KLK3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.|
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Provided below are standard protocols that you may find useful for product applications.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK3 is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma.
Binnie, M.C., et al., Prostate 63(4):309-315 (2005).Habib, F.K., et al., Int. J. Cancer 114(2):190-194 (2005).Laidler, P., et al., Arch. Biochem. Biophys. 435(1):1-14 (2005).Dallas, S.L., et al., J. Cell. Physiol. 202(2):361-370 (2005).Olsson, A.Y., et al., Genomics 84(1):147-156 (2004).
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