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Kallikrein 3 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P07288
Clone Names 4032906
Additional Information
Gene ID 354
Other Names Prostate-specific antigen, PSA, Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase, KLK3, APS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6322b was selected from the C-term region of human KLK3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLK3
Synonyms APS
Function Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Cellular Location Secreted.
Research Areas
Citations (0)
citation

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Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK3 is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma.

References

Binnie, M.C., et al., Prostate 63(4):309-315 (2005).Habib, F.K., et al., Int. J. Cancer 114(2):190-194 (2005).Laidler, P., et al., Arch. Biochem. Biophys. 435(1):1-14 (2005).Dallas, S.L., et al., J. Cell. Physiol. 202(2):361-370 (2005).Olsson, A.Y., et al., Genomics 84(1):147-156 (2004).

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$ 277.78
Cat# BP6322b
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