DSCR5 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P57054 |
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Clone Names | 2093006 |
Gene ID | 51227 |
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Other Names | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region protein 5, Down syndrome critical region protein C, Phosphatidylinositol-glycan biosynthesis class P protein, PIG-P, PIGP, DCRC, DSCR5, DSCRC |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6322c was selected from the Center region of human DSCR5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PIGP (HGNC:3046) |
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Synonyms | DCRC, DSCR5, DSCRC |
Function | Part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. |
Cellular Location | Membrane; Multi-pass membrane protein |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DSCR5 is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. DSCR5 is an N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). The DSCR5 gene is located in the Down Syndrome critical region (DSCR) on chromosome 21 and is a candidate for the pathogenesis of Down syndrome.
References
Choi, D.K., et al., Mamm. Genome 12(5):347-351 (2001).Togashi, T., et al., DNA Res. 7(3):207-212 (2000).Watanabe, R., et al., EMBO J. 19(16):4402-4411 (2000).Shibuya, K., et al., Biochem. Biophys. Res. Commun. 271(3):693-698 (2000).
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