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DSCR8 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96T75
Clone Names 2093009
Additional Information
Other Names Down syndrome critical region protein 8, Cancer/testis antigen 25, CT25, Malignant melanoma-associated protein 1, MMA-1, Protein MTAG2, DSCR8, C21orf65, MTAG2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6322f was selected from the N-term region of human DSCR8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DSCR8
Synonyms C21orf65, MTAG2
Tissue Location Expressed in numerous tissues; not found in breast, heart, small intestine and liver EMBL; AJ297914; CAC82786.1; -; mRNA EMBL; AJ306840; CAC84765.1; -; mRNA EMBL; AJ306839; CAC84766.1; -; mRNA EMBL; AJ301615; CAD29791.1; -; mRNA EMBL; AF321193; AAK52673.1; -; mRNA EMBL; AF426256; AAM53512.1; -; mRNA EMBL; AP001417; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC015981; -; NOT_ANNOTATED_CDS; mRNA UniGene; Hs.733345; - ProteinModelPortal; Q96T75; - IntAct; Q96T75; 2 STRING; 9606.ENSP00000350336; - PaxDb; Q96T75; - PRIDE; Q96T75; - Ensembl; ENST00000357704; ENSP00000350336; ENSG00000198054. [Q96T75-1] Ensembl; ENST00000400477; ENSP00000383325; ENSG00000198054. [Q96T75-3] Ensembl; ENST00000614538; ENSP00000480061; ENSG00000198054. [Q96T75-1] UCSC; uc062abe.1; human. [Q96T75-1] DisGeNET; 84677; - GeneCards; DSCR8; - H-InvDB; HIX0040871; - HGNC; HGNC:16707; DSCR8 HPA; HPA067047; - MIM; 613396; gene neXtProt; NX_Q96T75; - OpenTargets; ENSG00000198054; - eggNOG; ENOG410KIIZ; Eukaryota eggNOG; ENOG4110Q6S; LUCA GeneTree; ENSGT00390000000582; - HOGENOM; HOG000112279; - InParanoid; Q96T75; - OMA; EILMPQP; - OrthoDB; EOG091G0YYK; - PhylomeDB; Q96T75; - TreeFam; TF341571; - BioCyc; ZFISH:G66-32420-MONOMER; - PRO; PR:Q96T75; - Proteomes; UP000005640; Chromosome 21 Bgee; ENSG00000198054; - CleanEx; HS_DSCR8; - Genevisible; Q96T75; HS 1: Evidence at protein level; Alternative splicing; Complete proteome; Reference proteome CHAIN 1 97 Down syndrome critical region protein 8 /FTId=PRO_0000080021 VAR_SEQ 1 27 Missing (in isoform 2) {ECO:0000303|Ref.1} /FTId=VSP_003856 VAR_SEQ 28 37 LFLSPRLECS -> QTLEIKKVLE (in isoform 4) {ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1} /FTId=VSP_003859 VAR_SEQ 28 33 Missing (in isoform 3) {ECO:0000303|PubMed:12036297, ECO:0000303|PubMed:12213769, ECO:0000303|Ref.1} /FTId=VSP_003858 VAR_SEQ 28 32 LFLSP -> MYSYW (in isoform 2) {ECO:0000303|Ref.1} /FTId=VSP_003857 VAR_SEQ 38 97 Missing (in isoform 4) {ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1} /FTId=VSP_003860 SEQUENCE 97 AA; 10969 MW; 6A59E035E03285C4 CRC64; MKEPGPNFVT VRKGLHSFKM AFVKHLLLFL SPRLECSGSI TDHCSLHLPV QEILMSQPPE QLGLQTNLGN QESSGMMKLF MPRPKVLAQY ESIQFMP
Research Areas
Citations (0)

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Background

Down syndrome, which is the most common birth defect, is caused by trisomy 21. Studies of patients with partial trisomy 21 have defined a 1.6-Mb region between the DNA marker LA68 and ERG in 21q22.2 as the Down syndrome critical region (DSCR). DSCR8 is expressed in numerous tissues, but is not found in breast, heart, small intestine and liver.

References

Toyoda, A., et al., Genome Res. 12(9):1323-1332 (2002).Reymond, A., et al., Genomics 79(6):824-832 (2002).de Wit, N.J., et al., Int. J. Cancer 98(4):547-553 (2002).Dahmane, N., et al., Genomics 48(1):12-23 (1998).

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$ 80.00
Cat# BP6322f
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