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Kallikrein 4 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y5K2
Clone Names 4032908
Additional Information
Gene ID 9622
Other Names Kallikrein-4, 3421-, Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Prostase, Serine protease 17, KLK4, EMSP1, PRSS17, PSTS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6323b was selected from the C-term region of human KLK4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLK4
Synonyms EMSP1, PRSS17, PSTS
Function Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in prostate.
Research Areas
Citations (0)
citation

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Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In some tissues KLK4 expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins.

References

Hart, P.S., et al., J. Med. Genet. 41(7):545-549 (2004).Xi, Z., et al., Cancer Res. 64(7):2365-2370 (2004).Hural, J.A., et al., J. Immunol. 169(1):557-565 (2002).Takayama, T.K., et al., Biochemistry 40(50):15341-15348 (2001).Korkmaz, K.S., et al., DNA Cell Biol. 20(7):435-445 (2001).

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$ 277.78
Cat# BP6323b
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