|Other Names||Kallikrein-4, 3421-, Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Prostase, Serine protease 17, KLK4, EMSP1, PRSS17, PSTS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6323b was selected from the C-term region of human KLK4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||EMSP1, PRSS17, PSTS|
|Function||Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).|
|Tissue Location||Expressed in prostate.|
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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In some tissues KLK4 expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins.
Hart, P.S., et al., J. Med. Genet. 41(7):545-549 (2004).Xi, Z., et al., Cancer Res. 64(7):2365-2370 (2004).Hural, J.A., et al., J. Immunol. 169(1):557-565 (2002).Takayama, T.K., et al., Biochemistry 40(50):15341-15348 (2001).Korkmaz, K.S., et al., DNA Cell Biol. 20(7):435-445 (2001).
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