|Other Names||Kallikrein-5, 3421-, Kallikrein-like protein 2, KLK-L2, Stratum corneum tryptic enzyme, KLK5, SCTE|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6324a was selected from the N-term region of human KLK5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in desquamation.|
|Tissue Location||Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin|
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Provided below are standard protocols that you may find useful for product applications.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK5 expression is up-regulated by estrogens and progestins. The protein is secreted and may be involved in desquamation in the epidermis.
Planque, C., et al., Biochem. Biophys. Res. Commun. 329(4):1260-1266 (2005).Michael, I.P., et al., J. Biol. Chem. 280(15):14628-14635 (2005).Ishida-Yamamoto, A., et al., J. Invest. Dermatol. 124(2):360-366 (2005).Brattsand, M., et al., J. Invest. Dermatol. 124(1):198-203 (2005).Caubet, C., et al., J. Invest. Dermatol. 122(5):1235-1244 (2004).
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