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Kallikrein 7 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P49862
Clone Names 4033102
Peptide ID 4033102
Additional Information
Gene ID 5650
Other Names Kallikrein-7, hK7, Serine protease 6, Stratum corneum chymotryptic enzyme, hSCCE, KLK7, PRSS6, SCCE
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6326b was selected from the C-term region of human KLK7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLK7
Synonyms PRSS6, SCCE
Function May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6- Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
Cellular Location Secreted. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front
Tissue Location Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).
Research Areas
Citations (0)

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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK7 enzyme is thought to be involved in the proteolysis of intercellular cohesive structures preceding desquamation, which is the shedding of the outermost layer of the epidermis.


Planque, C., et al., Biochem. Biophys. Res. Commun. 329(4):1260-1266 (2005).Ishida-Yamamoto, A., et al., J. Invest. Dermatol. 124(2):360-366 (2005).Vasilopoulos, Y., et al., J. Invest. Dermatol. 123(1):62-66 (2004).Santin, A.D., et al., Gynecol. Oncol. 94(2):283-288 (2004).Caubet, C., et al., J. Invest. Dermatol. 122(5):1235-1244 (2004).

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$ 80.00
Cat# BP6326b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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