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Kallikrein 8 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60259 |
|---|---|
| Clone Names | 4033104 |
| Gene ID | 11202 |
|---|---|
| Other Names | Kallikrein-8, hK8, Neuropsin, NP, Ovasin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, KLK8, NRPN, PRSS19, TADG14 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6327b was selected from the Center region of human KLK8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KLK8 |
|---|---|
| Synonyms | NRPN, PRSS19, TADG14 |
| Function | Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. |
| Cellular Location | Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes |
| Tissue Location | Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. There are four different KLK8 isoforms, each exhibiting distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.
References
Li, Y., et al., Mol. Biol. Evol. 21(11):2111-2115 (2004).Shigemasa, K., et al., Oncol. Rep. 11(6):1153-1159 (2004).Cane, S., et al., Am. J. Obstet. Gynecol. 190(1):60-66 (2004).Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Magklara, A., et al., Clin. Cancer Res. 7(4):806-811 (2001).
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