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hCLC1-G972 Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P35523
Other Accession P35524, Q64347
Additional Information
Gene ID 1180
Other Names Chloride channel protein 1, ClC-1, Chloride channel protein, skeletal muscle, CLCN1, CLC1
Target/Specificity The synthetic peptide sequence is selected from aa 972~988 of HUMAN CLCN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLCN1
Synonyms CLC1
Function Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Predominantly expressed in skeletal muscles.
Research Areas
Citations (0)

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The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen).


Jou, S.B., et al., J. Neurol. 251(6):666-670 (2004).
Hebeisen, S., et al., J. Biol. Chem. 279(13):13140-13147 (2004).
Letizia, C., et al., Calcif. Tissue Int. 74(1):42-46 (2004).
Estevez, R., et al., Neuron 38(1):47-59 (2003).
Pusch, M., Hum. Mutat. 19(4):423-434 (2002).

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$ 80.00
$ 99.00
Cat# BP6329c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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