|Other Names||H(+)/Cl(-) exchange transporter 4, Chloride channel protein 4, ClC-4, Chloride transporter ClC-4, CLCN4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6329f was selected from the C-term region of human CLC4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.|
|Cellular Location||Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein|
|Tissue Location||Abundant in skeletal muscle and also detectable in brain and heart|
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The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.
Wang, T., et al., Gastroenterology 126(4):1157-1166 (2004).Lamb, F.S., et al., J. Mol. Cell. Cardiol. 31(3):657-666 (1999).Dinulos, M.B., et al., Genomics 35(1):244-247 (1996).Schnur, R.E., et al., Hum. Genet. 95(5):594-595 (1995).van Slegtenhorst, M.A., et al., Hum. Mol. Genet. 3(4):547-552 (1994).
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