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CLC5 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P51795 |
|---|---|
| Clone Names | 2021812 |
| Gene ID | 1184 |
|---|---|
| Other Names | H(+)/Cl(-) exchange transporter 5, Chloride channel protein 5, ClC-5, Chloride transporter ClC-5, CLCN5, CLCK2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6329g was selected from the C-term region of human CLC5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLCN5 (HGNC:2023) |
|---|---|
| Synonyms | CLCK2 |
| Function | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:20466723). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CLCN5 is a voltage-gated chloride channel. Mutation of this gene results in Dent disease and renal tubular disorders complicated by nephrolithiasis.
References
Jouret, F., et al., Kidney Int. 65(1):198-208 (2004).Moulin, P., et al., Kidney Int. 63(4):1285-1295 (2003).Claverie-Martin, F., et al., Hum. Genet. 113(6):480-485 (2003).Hryciw, D.H., et al., J. Biol. Chem. 278(41):40169-40176 (2003).Carballo-Trujillo, I., et al., Nephrol. Dial. Transplant. 18(4):717-723 (2003).
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