|Other Names||H(+)/Cl(-) exchange transporter 5, Chloride channel protein 5, ClC-5, Chloride transporter ClC-5, CLCN5, CLCK2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6329g was selected from the C-term region of human CLC5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle|
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Provided below are standard protocols that you may find useful for product applications.
CLCN5 is a voltage-gated chloride channel. Mutation of this gene results in Dent disease and renal tubular disorders complicated by nephrolithiasis.
Jouret, F., et al., Kidney Int. 65(1):198-208 (2004).Moulin, P., et al., Kidney Int. 63(4):1285-1295 (2003).Claverie-Martin, F., et al., Hum. Genet. 113(6):480-485 (2003).Hryciw, D.H., et al., J. Biol. Chem. 278(41):40169-40176 (2003).Carballo-Trujillo, I., et al., Nephrol. Dial. Transplant. 18(4):717-723 (2003).
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