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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Kallikrein 11 Antibody (Center) Blocking peptide   

Kallikrein 11 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UBX7
Clone Names 4033110
Additional Information
Gene ID 11012
Other Names Kallikrein-11, hK11, 3421-, Hippostasin, Serine protease 20, Trypsin-like protease, Kallikrein-11 inactive chain 1, Kallikrein-11 inactive chain 2, KLK11, PRSS20, TLSP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6330b was selected from the Center region of human KLK11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLK11
Synonyms PRSS20, TLSP
Function Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Cellular Location Isoform 1: Secreted.
Tissue Location Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level)
Research Areas
Citations (0)

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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK11, also known as hippostatin, is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain-type and prostate-type. KLK11 plays a role in the prostate, including reproductive and/or tumorigenic functions. Elevated serum levels of KLLK11 are found in 70% of women with ovarian cancer and in 60% of men with prostate cancer. Analysis of the KLK11 biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma.


Diamandis, E.P., et al., Clin. Biochem. 37(9):823-829 (2004).Shigemasa, K., et al., Clin. Cancer Res. 10(8):2766-2770 (2004).Borgono, C.A., et al., Int. J. Cancer 106(4):605-610 (2003).Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Nakamura, T., et al., Urology 61(5):1042-1046 (2003).

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$ 80.00
Cat# BP6330b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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