|Other Names||Calcium-activated chloride channel regulator 1, 34--, Calcium-activated chloride channel family member 1, hCLCA1, Calcium-activated chloride channel protein 1, CaCC-1, hCaCC-1, CLCA1, CACC1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6335a was selected from the N-term region of human CLCA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.|
|Cellular Location||Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli|
|Tissue Location||Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients Expressed in the bronchial epithelium, especially in mucus- producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.|
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Provided below are standard protocols that you may find useful for product applications.
CLCA1 belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene product is expressed predominantly in the small intestine and colon mucosa, and may be involved in secretory or absorptive processes.
Ritzka, M., et al., Hum. Genet. 115(6):483-491 (2004).Kamada, F., et al., Genes Immun. 5(7):540-547 (2004).Greenwood, I.A., et al., J. Biol. Chem. 277(25):22119-22122 (2002).Loewen, M.E., et al., Biochem. Biophys. Res. Commun. 298(4):531-536 (2002).Toda, M., et al., J. Allergy Clin. Immunol. 109(2):246-250 (2002).
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