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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Glypican 3 (GPC3) Antibody (N-term) Blocking peptide   

Glypican 3 (GPC3) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P51654
Clone Names 3112101
Additional Information
Gene ID 2719
Other Names Glypican-3, GTR2-2, Intestinal protein OCI-5, MXR7, Secreted glypican-3, GPC3, OCI5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6337a was selected from the N-term region of human GPC3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPC3
Synonyms OCI5
Function Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
Tissue Location Highly expressed in lung, liver and kidney.
Research Areas
Citations (0)

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GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.


Nakatsura, T., et al., Clin. Cancer Res. 10(19):6612-6621 (2004).Boily, G., et al., Br. J. Cancer 90(8):1606-1611 (2004).Wichert, A., et al., Oncogene 23(4):945-955 (2004).Midorikawa, Y., et al., Int. J. Cancer 103(4):455-465 (2003).Sung, Y.K., et al., Cancer Sci. 94(3):259-262 (2003).

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$ 80.00
Cat# BP6337a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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