|Other Names||Kinesin heavy chain isoform 5A, Kinesin heavy chain neuron-specific 1, Neuronal kinesin heavy chain, NKHC, Kif5a, Kiaa4086, Kif5, Nkhc1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6349a was selected from the C-term region of human Mouse Kif5A-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||Kiaa4086, Kif5, Nkhc1|
|Function||Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (PubMed:12682084). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons (PubMed:21976701).|
|Cellular Location||Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region|
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Provided below are standard protocols that you may find useful for product applications.
Kif5A is a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this protein cause autosomal dominant spastic paraplegia 10.
Fichera, M., et al., Neurology 63(6):1108-1110 (2004). Reid, E., et al., Am. J. Hum. Genet. 71(5):1189-1194 (2002). Kanai, Y., et al., J. Neurosci. 20(17):6374-6384 (2000). Reid, E., et al., Am. J. Hum. Genet. 65(3):757-763 (1999). Rahman, A., et al., J. Cell Biol. 146(6):1277-1288 (1999).
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