Mouse Kif5A-1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P33175 |
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Other Accession | Q6PDY7 |
Clone Names | 4111101 |
Gene ID | 16572 |
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Other Names | Kinesin heavy chain isoform 5A, Kinesin heavy chain neuron-specific 1, Neuronal kinesin heavy chain, NKHC, Kif5a, Kiaa4086, Kif5, Nkhc1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6349a was selected from the C-term region of human Mouse Kif5A-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Kif5a |
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Synonyms | Kiaa4086, Kif5, Nkhc1 |
Function | Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (PubMed:12682084). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons (PubMed:21976701). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). |
Cellular Location | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6QLM7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6QLM7}. Perikaryon {ECO:0000250|UniProtKB:Q6QLM7}. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region {ECO:0000250|UniProtKB:Q6QLM7} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Kif5A is a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this protein cause autosomal dominant spastic paraplegia 10.
References
Fichera, M., et al., Neurology 63(6):1108-1110 (2004). Reid, E., et al., Am. J. Hum. Genet. 71(5):1189-1194 (2002). Kanai, Y., et al., J. Neurosci. 20(17):6374-6384 (2000). Reid, E., et al., Am. J. Hum. Genet. 65(3):757-763 (1999). Rahman, A., et al., J. Cell Biol. 146(6):1277-1288 (1999).
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