|Other Names||Kinesin heavy chain isoform 5C, Kinesin heavy chain neuron-specific 2, Kif5c, Nkhc2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6350a was selected from the C-term region of human Mouse Kif5C-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Mediates dendritic trafficking of mRNAs.|
|Cellular Location||Cytoplasm, cytoskeleton.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Kinesins are microtubule-based motor proteins involved in the transport of organelles in eukaryotic cells. They typically consist of 2 identical, approximately 110- to 120-kD heavy chains and 2 identical, approximately 60- to 70-kD light chains. The heavy chain contains 3 domains: a globular N-terminal motor domain, which converts the chemical energy of ATP into a motile force along microtubules in 1 fixed direction; a central alpha-helical rod domain, which enables the 2 heavy chains to dimerize; and a globular C-terminal domain, which interacts with light chains and possibly an organelle receptor.
Yang,J. et al. Exp. Cell Res. 309 (2), 379-389 (2005)Teng,J. et al. Nat. Cell Biol. 7 (5), 474-482 (2005)Kanai,Y. et al. Neuron 43 (4), 513-525 (2004)Cai,Y. et al. J. Biol. Chem. 276 (45), 41594-41602 (2001)Kanai,Y. et al. J. Neurosci. 20 (17), 6374-6384 (2000)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.