|Other Names||Kinesin heavy chain isoform 5C, Kinesin heavy chain neuron-specific 2, Kif5c, Nkhc2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6350a was selected from the C-term region of human Mouse Kif5C-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Mediates dendritic trafficking of mRNAs.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
Kinesins are microtubule-based motor proteins involved in the transport of organelles in eukaryotic cells. They typically consist of 2 identical, approximately 110- to 120-kD heavy chains and 2 identical, approximately 60- to 70-kD light chains. The heavy chain contains 3 domains: a globular N-terminal motor domain, which converts the chemical energy of ATP into a motile force along microtubules in 1 fixed direction; a central alpha-helical rod domain, which enables the 2 heavy chains to dimerize; and a globular C-terminal domain, which interacts with light chains and possibly an organelle receptor.
Yang,J. et al. Exp. Cell Res. 309 (2), 379-389 (2005)Teng,J. et al. Nat. Cell Biol. 7 (5), 474-482 (2005)Kanai,Y. et al. Neuron 43 (4), 513-525 (2004)Cai,Y. et al. J. Biol. Chem. 276 (45), 41594-41602 (2001)Kanai,Y. et al. J. Neurosci. 20 (17), 6374-6384 (2000)
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