|Other Names||Unconventional myosin-Vc, MYO5C|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6354a was selected from the Center region of human MYO5C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.|
|Tissue Location||Expressed chiefly in non-neuronal tissues. Particularly abundant in epithelial and glandular tissues including pancreas, prostate, mammary, stomach, colon and lung|
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The MYO5C gene encodes a 1,742-amino acid protein with a predicted molecular mass of 203 kD that shares approximately 50% identity with family members MYO5A (160777) and MYO5B (606540). The MYO5C protein consists of a motor domain followed by 6 IQ motifs, a coiled-coil region, and a C-terminal globular domain. MYO5C contains a serine residue conserved among all 3 class V myosins whose phosphorylation in MYO5A regulates melanosome binding; however, MYO5C does not contain the PEST region present in MYO5A and MYO5B.Myo5c was found specifically in the apical regions of intestinal epithelial cells and in exocrine pancreas.
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Bement, W.M., et al., Proc. Natl. Acad. Sci. U.S.A. 91(14):6549-6553 (1994).Rodriguez, O.C., et al., J. Cell. Sci. 115 (Pt 5), 991-1004 (2002) (): ().
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