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IL3RB Blocking Peptide (C-term V759)

Synthetic peptide

     
  • SPECIFICATION
  • CITATIONS
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Product Information
Primary Accession P32927
Additional Information
Gene ID 1439
Other Names Cytokine receptor common subunit beta, CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, CD131, CSF2RB, IL3RB, IL5RB
Target/Specificity The synthetic peptide sequence is selected from aa 759-773 of HUMAN CSF2RB
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSF2RB
Synonyms IL3RB, IL5RB
Function Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK- STAT pathway (PubMed:9516124).
Cellular Location Membrane; Single-pass type I membrane protein.
Research Areas
Citations (0)
citation

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Background

Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein G affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

References

Murphy, J.M., et al., J. Biol. Chem. 279(25):26500-26508 (2004).
McClure, B.J., et al., Blood 101(4):1308-1315 (2003).
Scibek, J.J., et al., Anal. Biochem. 307(2):258-265 (2002).
Blake, T.J., et al., J. Leukoc. Biol. 72(6):1246-1255 (2002).
Evans, C.A., et al., Blood 100(9):3164-3174 (2002).

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$ 277.78
Cat# BP6360b
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