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MYO3A Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NEV4 |
|---|---|
| Clone Names | 70411274 |
| Gene ID | 53904 |
|---|---|
| Other Names | Myosin-IIIa, MYO3A |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6371b was selected from the C-term region of human MYO3A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MYO3A |
|---|---|
| Function | Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm. Cell projection, filopodium tip. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q8K3H5}. Note=Increased localization at the filodium tip seen in the presence of MORN4 |
| Tissue Location | Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
MYO3A belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. This protein plays an important role in hearing in humans. Three different recessive loss of function mutations have been shown to cause nonsyndromic progressive hearing loss.
References
Dose,A.C., J. Biol. Chem. 282 (1), 216-231 (2007)Kambara,T., J. Biol. Chem. 281 (49), 37291-37301 (2006)
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