|Other Names||Myosin-IIIa, MYO3A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6371b was selected from the C-term region of human MYO3A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
MYO3A belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. This protein plays an important role in hearing in humans. Three different recessive loss of function mutations have been shown to cause nonsyndromic progressive hearing loss.
Dose,A.C., J. Biol. Chem. 282 (1), 216-231 (2007)Kambara,T., J. Biol. Chem. 281 (49), 37291-37301 (2006)
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