|Other Names||Transforming growth factor beta regulator 1, Nuclear interactor of ARF and Mdm2, TBRG1, NIAM|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6376a was selected from the N-term region of human TBRG1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.|
|Tissue Location||Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma|
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Provided below are standard protocols that you may find useful for product applications.
TBRG1 acts as a growth inhibitor. It can activate TP53/p53, cause G1 arrest and collaborate with CDKN2A to restrict proliferation, but it does not require either protein to inhibit DNA synthesis. TBRG1 redistributes CDKN2A into the nucleoplasm, and is involved in maintaining chromosomal stability.
Tompkins,V.S., J. Biol. Chem. 282 (2), 1322-1333 (2007)Babalola,G.O.,Mol. Reprod. Dev. 41 (2), 133-139 (1995)
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