|Other Names||Phospholipase D1, PLD 1, hPLD1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1, PLD1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6377a was selected from the N-term region of human PLD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).|
|Cellular Location||Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Late endosome membrane; Lipid- anchor; Cytoplasmic side|
|Tissue Location||Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 184.108.40.206) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis (Hammond et al., 1995 [PubMed 8530346]).[supplied by OMIM]
Sun,Y., Proc. Natl. Acad. Sci. U.S.A. 105 (24), 8286-8291 (2008)Sethu,S., J. Immunol. 180 (9), 6027-6034 (2008)Nagasaki,A., Cell Struct. Funct. 33 (1), 27-33 (2008)
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