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RHEB Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15382
Clone Names 71211160
Peptide ID 71211160
Additional Information
Gene ID 6009
Other Names GTP-binding protein Rheb, Ras homolog enriched in brain, RHEB, RHEB2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6378c was selected from the Center region of human RHEB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RHEB2
Function Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Cellular Location Endomembrane system {ECO:0000269|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side
Tissue Location Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Research Areas
Citations (0)

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RHEB is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity.


Sun,Y., Proc. Natl. Acad. Sci. U.S.A. 105 (24), 8286-8291 (2008)Bai,X., Science 318 (5852), 977-980 (2007)

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$ 80.00
Cat# BP6378c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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