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FGF1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P05230
Clone Names 71213106
Peptide ID 71213106
Additional Information
Gene ID 2246
Other Names Fibroblast growth factor 1, FGF-1, Acidic fibroblast growth factor, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1, HBGF-1, FGF1, FGFA
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6379a was selected from the N-term region of human FGF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGF1
Synonyms FGFA
Function Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Cellular Location Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
Tissue Location Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle
Research Areas
Citations (0)

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FGF1 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis.


Fukushima,S., Int. J. Oncol. 32 (2), 467-473 (2008)Riley,B.M.Am. J. Med. Genet. A 143 (24), 3228-3234 (2007)Tomaszewski,M.,Circulation 116 (17), 1915-1924 (2007)

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$ 80.00
Cat# BP6379a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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