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FXN Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q16595
Clone Names 70411226
Peptide ID 70411226
Additional Information
Gene ID 2395
Other Names Frataxin, mitochondrial, Friedreich ataxia protein, Fxn, Frataxin intermediate form, i-FXN, Frataxin(56-210), m56-FXN, Frataxin(78-210), d-FXN, m78-FXN, Frataxin mature form, Frataxin(81-210), m81-FXN, FXN, FRDA, X25
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6409c was selected from the Center region of human FXN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FXN
Synonyms FRDA, X25
Function Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.
Cellular Location Cytoplasm. Mitochondrion. Note=PubMed:18725397 reports localization exclusively in mitochondria
Tissue Location Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts.
Research Areas
Citations (0)

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FXN is a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia.

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$ 80.00
Cat# BP6409c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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