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STUB1 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UNE7
Other Accession Q969U2
Clone Names 4123058
Peptide ID 4123058
Additional Information
Gene ID 10273
Other Names E3 ubiquitin-protein ligase CHIP, 632-, Antigen NY-CO-7, CLL-associated antigen KW-8, Carboxy terminus of Hsp70-interacting protein, STIP1 homology and U box-containing protein 1 {ECO:0000312|HGNC:HGNC:11427}, STUB1 (HGNC:11427)
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6413b was selected from the STUB1 region of human CHIP (STUB1). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STUB1 (HGNC:11427)
Function E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223).
Cellular Location Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg)
Tissue Location Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung
Research Areas
Citations (0)

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CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase(s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease.


Peng,H.M., et al. J. Biol. Chem. 279 (51), 52970-52977 (2004)Alberti,S., et al. Mol. Biol. Cell 15 (9), 4003-4010 (2004)Beausoleil,S.A., et al. PNAS 101 (33), 12130-12135 (2004)He,B., et al. J. Biol. Chem. 279 (29), 30643-30653 (2004)Petrucelli,L., et al. Hum. Mol. Genet. 13 (7), 703-714 (2004)Shimura,H., et al. J. Biol. Chem. 279 (6), 4869-4876 (2004)Li,L., et al. Mol. Cell. Biol. 24 (2), 856-864 (2004)Zhou,P., et al. J. Biol. Chem. 278 (16), 13829-13837 (2003)Imai,Y., et al. Mol. Cell 10 (1), 55-67 (2002)Ballinger,C.A., et al. Mol. Cell. Biol. 19 (6), 4535-4545 (1999)

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$ 80.00
Cat# BP6413b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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