|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6416a was selected from the C-term region of human Drosophila DJ-1A (C-term). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in protection against reactive oxygen species (ROS) (By similarity) (PubMed:16139213). Does not play a role in methylglyoxal detoxification (By similarity).|
|Tissue Location||Expressed in testis (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
DJ-1 mutations are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1 is suggested to normally function as a redox-sensitive molecular chaperone protective against cellular oxidative stress. DJ-1 drosophila models are an important tool for elucidating protein function and for modeling neurodegenerative disease.
Moore DJ, et al. Sci Aging Knowledge Environ. 2006 Jan 11;2006(2):pe2.Park J, et al. Gene. 2005 Nov 21;361:133-9.Yang Y, et al. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13670-5. Menzies FM, et al. Curr Biol. 2005 Sep 6;15(17):1578-82. Meulener M, et al. Curr Biol. 2005 Sep 6;15(17):1572-7. Meulener M, et al. J Neurochem. 2005 Jun;93(6):1524-32.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.