|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6416a was selected from the C-term region of human Drosophila DJ-1A (C-term). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in protection against reactive oxygen species (ROS) (By similarity) (PubMed:16139213). Does not play a role in methylglyoxal detoxification (By similarity).|
|Tissue Location||Expressed in testis (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
DJ-1 mutations are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1 is suggested to normally function as a redox-sensitive molecular chaperone protective against cellular oxidative stress. DJ-1 drosophila models are an important tool for elucidating protein function and for modeling neurodegenerative disease.
Moore DJ, et al. Sci Aging Knowledge Environ. 2006 Jan 11;2006(2):pe2.Park J, et al. Gene. 2005 Nov 21;361:133-9.Yang Y, et al. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13670-5. Menzies FM, et al. Curr Biol. 2005 Sep 6;15(17):1578-82. Meulener M, et al. Curr Biol. 2005 Sep 6;15(17):1572-7. Meulener M, et al. J Neurochem. 2005 Jun;93(6):1524-32.
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