|Other Names||Serine--pyruvate aminotransferase, SPT, Alanine--glyoxylate aminotransferase, AGT, AGXT, AGT1, SPAT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6500c was selected from the Center region of human AGXT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Peroxisome. Mitochondrion Note=Predominantly localized in the peroxisomes. Mitochondrial mistargeting occurs in variant proteins Arg-41, Arg-47, Ile-152, Arg-170 and Thr-244 associated with the disease HP1|
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Provided below are standard protocols that you may find useful for product applications.
AGXT is expressed only in the liver and protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification.
Cellini,B., J. Biol. Chem. 284 (13), 8349-8358 (2009)Bertoldi,M., Biochim. Biophys. Acta 1784 (9), 1356-1362 (2008)
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