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ALS2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96Q42
Clone Names 80722012
Additional Information
Gene ID 57679
Other Names Alsin, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis 2 protein, ALS2, ALS2CR6, KIAA1563
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6501b was selected from the C-term region of human ALS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALS2
Synonyms ALS2CR6, KIAA1563
Function May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity).
Research Areas
Citations (0)

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ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in its gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.


Soares,D.C., J Mol Model 15 (2), 113-122 (2009)Mintchev,N., Neurology 72 (1), 28-32 (2009)

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$ 80.00
Cat# BP6501b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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