IL1RN Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P18510 |
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Clone Names | 80703023 |
Gene ID | 3557 |
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Other Names | Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra, IL1RN, IL1F3, IL1RA |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6503b was selected from the C-term region of human IL1RN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IL1RN |
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Synonyms | IL1F3, IL1RA |
Function | Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. |
Cellular Location | [Isoform 1]: Secreted [Isoform 3]: Cytoplasm. |
Tissue Location | The intracellular form of IL1RN is predominantly expressed in epithelial cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of its gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer.
References
Kumar,S., Biochem. Biophys. Res. Commun. 387 (3), 456-460 (2009)Rechcinski,T., Kardiol Pol 67 (6), 601-610 (2009)
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