|Other Names||UDP-glucuronosyltransferase 2B17, UDPGT 2B17, C19-steroid-specific UDP-glucuronosyltransferase, C19-steroid-specific UDPGT, UGT2B17|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6505c was selected from the Center region of human UDB17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).|
|Cellular Location||Microsome membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate|
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Provided below are standard protocols that you may find useful for product applications.
UGT2B17 belongs to the family of UDP-glucuronosyltransferases (UGTs; EC 184.108.40.206), enzymes that catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones.
Balliet,R.M., Cancer Res. 69 (7), 2981-2989 (2009)Juul,A., J. Clin. Endocrinol. Metab. 94 (3), 1005-1011 (2009)
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