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HAT Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O60235
Clone Names 80513191
Peptide ID 80513191
Additional Information
Gene ID 9407
Other Names Transmembrane protease serine 11D, 3421-, Airway trypsin-like protease, Transmembrane protease serine 11D non-catalytic chain, Transmembrane protease serine 11D catalytic chain, TMPRSS11D, HAT
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6510c was selected from the Center region of human HAT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HAT
Function May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence.
Cellular Location Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted
Tissue Location Located in the cells of the submucosal serous glands of the bronchi and trachea
Research Areas
Citations (0)

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HAT is a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.


Bottcher,E., J. Virol. 80 (19), 9896-9898 (2006)

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$ 80.00
Cat# BP6510c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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