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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   SUV4-20H2 Antibody (Center) Blocking Peptide   

SUV4-20H2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86Y97
Clone Names 80513219
Peptide ID 80513219
Additional Information
Gene ID 84787
Other Names Histone-lysine N-methyltransferase SUV420H2, Lysine N-methyltransferase 5C, Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2, Suv4-20h2, SUV420H2, KMT5C
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6511c was selected from the Center region of human SUV4-20H2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KMT5C (HGNC:28405)
Synonyms SUV420H2
Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).
Cellular Location Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
Research Areas
Citations (0)

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Background

SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).

References

Souza,P.P., BMC Cell Biol. 10, 41 (2009)Tryndyak,V.P., Cancer Biol. Ther. 5 (1), 65-70 (2006)

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$ 80.00
Cat# BP6511c
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