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P450R Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P16435
Clone Names 80808137
Peptide ID 80808137
Additional Information
Gene ID 5447
Other Names NADPH--cytochrome P450 reductase, CPR, P450R, POR, CYPOR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6518a was selected from the N-term region of human P450R. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name POR {ECO:0000255|HAMAP-Rule:MF_03212}
Synonyms CYPOR
Function This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Cellular Location Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03212}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03212}
Research Areas
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Background

P450R is an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in its gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.

References

Fukami,M., J. Clin. Endocrinol. Metab. 94 (5), 1723-1731 (2009)Mast,N., Arch. Biochem. Biophys. 483 (1), 81-89 (2009)Brenner,S., FEBS J. 275 (18), 4540-4557 (2008)

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$ 80.00
Cat# BP6518a
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