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ARPC1A Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q92747
Clone Names 81006011
Additional Information
Gene ID 10552
Other Names Actin-related protein 2/3 complex subunit 1A, SOP2-like protein, ARPC1A, SOP2L
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6519c was selected from the Center region of human ARPC1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARPC1A
Synonyms SOP2L
Function Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Cellular Location Cytoplasm, cytoskeleton. Nucleus {ECO:0000250|UniProtKB:Q8AVT9}
Research Areas
Citations (0)
citation

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Background

ARPC1A is one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.

References

Laurila,E., Genes Chromosomes Cancer 48 (4), 330-339 (2009)Machesky,L.M., Biochem. J. 328 (PT 1), 105-112 (1997)

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$ 277.78
Cat# BP6519c
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