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EEF1D Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P29692 |
|---|---|
| Clone Names | 81006107 |
| Gene ID | 1936 |
|---|---|
| Other Names | Elongation factor 1-delta, EF-1-delta, Antigen NY-CO-4, EEF1D, EF1D |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6523a was selected from the N-term region of human EEF1D. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EEF1D |
|---|---|
| Synonyms | EF1D |
| Function | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. |
| Cellular Location | [Isoform 2]: Nucleus |
| Tissue Location | Isoform 2 is specifically expressed in brain, cerebellum and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
EEF1D is a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs.
References
Yang,S., BMC Cancer 7, 211 (2007)Mulner-Lorillon,O., J. Biol. Chem. 269 (31), 20201-20207 (1994)
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