|Other Names||Elongation factor 1-delta, EF-1-delta, Antigen NY-CO-4, EEF1D, EF1D|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6523a was selected from the N-term region of human EEF1D. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.|
|Cellular Location||Isoform 2: Nucleus|
|Tissue Location||Isoform 2 is specifically expressed in brain, cerebellum and testis|
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Provided below are standard protocols that you may find useful for product applications.
EEF1D is a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs.
Yang,S., BMC Cancer 7, 211 (2007)Mulner-Lorillon,O., J. Biol. Chem. 269 (31), 20201-20207 (1994)
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