|Other Names||Adiponectin, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, ACRP30, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein, ADIPOQ, ACDC, ACRP30, APM1, GBP28|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6531a was selected from the N-term region of human ACDC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACDC, ACRP30, APM1, GBP28|
|Function||Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.|
|Tissue Location||Synthesized exclusively by adipocytes and secreted into plasma|
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Provided below are standard protocols that you may find useful for product applications.
ACDC is expressed in adipose tissue exclusively. It is a protein with similarity to collagens X and VIII and complement factor C1q. The protein circulates in the plasma and is involved with metabolic and hormonal processes.
Wang,Y., J. Biol. Chem. 277 (22), 19521-19529 (2002)Schaffler,A., Biochim. Biophys. Acta 1399 (2-3), 187-197 (1998)
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