RSC1A1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q92681 |
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Clone Names | 80924182 |
Gene ID | 6248 |
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Other Names | Regulatory solute carrier protein family 1 member 1, Transporter regulator RS1, hRS1, RSC1A1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6534a was selected from the N-term region of human RSC1A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RSC1A1 |
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Function | Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network. |
Cellular Location | Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Localizes at the inner side of the plasma membrane |
Tissue Location | Expressed in small intestine, kidney and brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RSC1A1 mediates transcriptional and post-transcriptional regulation of SLC5A1. The protein inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1 and is also involved in transcriptional regulation of SLC22A2. It exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.
References
Vernaleken,A., J. Biol. Chem. 282 (39), 28501-28513 (2007)Kroiss,M., Am. J. Physiol. Renal Physiol. 291 (6), F1201-F1212 (2006)Veyhl,M., Am. J. Physiol. Renal Physiol. 291 (6), F1213-F1223 (2006)
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