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MXD4 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14582
Clone Names 80902044
Peptide ID 80902044
Additional Information
Gene ID 10608
Other Names Max dimerization protein 4, Max dimerizer 4, Class C basic helix-loop-helix protein 12, bHLHc12, Max-associated protein 4, Max-interacting transcriptional repressor MAD4, MXD4, BHLHC12, MAD4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6539a was selected from the N-term region of human MXD4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MXD4
Synonyms BHLHC12, MAD4
Function Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}
Research Areas
Citations (0)

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MXD4 is a member of the MAD gene family . The MAD, basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.


Marcotte,R., J. Cell. Biochem. 96 (5), 1071-1085 (2005)

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$ 80.00
Cat# BP6539a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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