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CPB2 Antibody (Center E134) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96IY4
Clone Names 80410133
Additional Information
Gene ID 1361
Other Names Carboxypeptidase B2, Carboxypeptidase U, CPU, Plasma carboxypeptidase B, pCPB, Thrombin-activable fibrinolysis inhibitor, TAFI, CPB2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6541c was selected from the Center region of human CPB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPB2
Function Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
Cellular Location Secreted.
Tissue Location Plasma; synthesized in the liver.
Research Areas
Citations (0)
citation

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Background

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for its gene and its promoter region.

References

Valnickova,Z., J. Biol. Chem. 271 (22), 12937-12943 (1996)

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$ 277.78
Cat# BP6541c
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Availability: 2 weeks
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