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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   RBL2/p130 Antibody (Center) Blocking Peptide   

RBL2/p130 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q08999
Clone Names 80722088
Peptide ID 80722088
Additional Information
Gene ID 5934
Other Names Retinoblastoma-like protein 2, 130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2, RBL2, RB2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6543c was selected from the Center region of human RBL2/p130. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RBL2
Synonyms RB2
Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

RBL2 is a key regulator of entry into cell division. The protein is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. It probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.

References

Priya,K., Cancer Biol. Ther. 8 (8), 714-717 (2009)Fields,A.L., J. Cell. Physiol. 217 (1), 77-85 (2008)Masciullo,V., Clin. Cancer Res. 14 (15), 4775-4779 (2008)

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$ 80.00
Cat# BP6543c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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