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RBL2/p130 Antibody (Center) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP6543c | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
RBL2/p130 Antibody (Center) Blocking Peptide - Product info | |
| Primary Accession | Q08999 |
| Clone Names | 80722088 |
| Calculated MW | 128367 Da |
RBL2/p130 Antibody (Center) Blocking Peptide - Additional info | |
| Gene ID 5934 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP6543c was selected from the Center region of human RBL2/p130. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
RBL2/p130 Antibody (Center) Blocking Peptide - Protein Information | |
| Name RBL2 | |
| Synonyms RB2 | |
| Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor | |
| Cellular Location Nucleus. | |
RBL2/p130 Antibody (Center) Blocking Peptide - Related products
AP12224a: RBL2 Antibody (N-term)
AP6543a: RBL2/p130 Antibody (N-term)
AP6543c: RBL2/p130 Antibody (Center)
BP6543a: RBL2/p130 Antibody (N-term) Blocking Peptide
BP6543c: RBL2/p130 Antibody (Center) Blocking Peptide
AT3590a: RBL2 Antibody (monoclonal) (M03)
AT3591a: RBL2 Antibody (monoclonal) (M05)
RBL2/p130 Antibody (Center) Blocking Peptide - Research Areas
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BACKGROUND
RBL2 is a key regulator of entry into cell division. The protein is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. It probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.
REFERENCES
Priya,K., Cancer Biol. Ther. 8 (8), 714-717 (2009)Fields,A.L., J. Cell. Physiol. 217 (1), 77-85 (2008)Masciullo,V., Clin. Cancer Res. 14 (15), 4775-4779 (2008)
