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HFE Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q30201 |
|---|---|
| Clone Names | 80703086 |
| Gene ID | 3077 |
|---|---|
| Other Names | Hereditary hemochromatosis protein, HLA-H, HFE, HLAH |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6544c was selected from the Center region of human HFE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HFE |
|---|---|
| Synonyms | HLAH |
| Function | Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in all tissues tested except brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in its gene.
References
Valenti,L., Clin J Am Soc Nephrol 4 (8), 1331-1337 (2009)Won,J.E., Intervirology 52 (5), 239-246 (2009)
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