|Other Names||Hereditary hemochromatosis protein, HLA-H, HFE, HLAH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6544c was selected from the Center region of human HFE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in all tissues tested except brain.|
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Provided below are standard protocols that you may find useful for product applications.
HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in its gene.
Valenti,L., Clin J Am Soc Nephrol 4 (8), 1331-1337 (2009)Won,J.E., Intervirology 52 (5), 239-246 (2009)
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