|Other Names||Carboxypeptidase Z, CPZ, 3417-, CPZ|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6546a was selected from the N-term region of human CPZ. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
CPZ is a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases.
Fan,X., J. Histochem. Cytochem. 50 (11), 1509-1516 (2002)Reznik,S.E., Cell. Mol. Life Sci. 58 (12-13), 1790-1804 (2001)
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